Cryoglobulinemia Symptoms

Cryoglobulinemia symptoms are different for each type.


Cryoglobulinemia type I is characterized by symptoms such as:

  • retinal haemorrhageretinal haemorrhage
  • Raynaud’s phenomenon
  • arterial thrombosis
  • acrocyanosis
  • arthralgias
  • myalgias

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What Is Mixed Cryoglobulinemia?

What is mixed cryoglobulinemia

Mixed CryoglobulinemiaCryoglobulinemia type II is also called mixed cryoglobulinemia. It’s defined by the presence of both cryoglobulins types: monoclonal and polyclonal. It is defined as secondary disease if it is accompanied by certain diseases such as autoimmune diseases, chronic inflammation, infections or cancer of the lymphatic system.  If there is no found cause of cryoglobulinemia symptoms then it’s called essential mixed cryoglobulinemia. In a large proportion of patients with idiopathic mixed cryoglobulinemia it is concluded hepatitis C.


The disease is chronic with periodic relapses. The indication for treatment is when the disease affects the kidneys, liver, or small vessels and peripheral nerves. Mixed cryoglobulinemia is the most common type of this disease.


Mixed cryoglobulinemia most fraquently occurs in middle-age woman.


Common symptoms of essential mixed cryoglobulinemia

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